The business environment, learner profiles, training environment, and IT infrastructure are all things that instructional designers consider in their design plans. By using our site, you acknowledge that you have read and understand our Privacy Policy Big Data has changed the customer experience, and because of this it is changing how UX designers view customers. Consequently, developers find few shortcuts (canned applications or usable components) that speed up deployments. This data is mainly generated in terms of photo and video uploads, message exchanges, putting comments etc. "Currently, most cancer treatments, including cell therapies, are told 'block this,' or 'kill this. Enterprise big data systems face a variety of data sources with non-relevant information (noise) alongside relevant (signal) data. Big Data Powers Design of ‘Smart’ Cell Therapies for Cancer Details Research 27 November 2020 Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. Big data powers design of 'smart' cell therapies for cancer. (ANI), AI predicts which drug combinations kill cancer cells, Highly effective measles virus-based Th1-biased coronavirus vaccine, Antidepressant helps to inhibit growth of cancer cells: Study, Breast cancer discovery could help stop disease's deadly spread: Study, Cold temperatures, Vitamin A capable of burning fat faster, says study, Existing antidepressant helps to inhibit growth of cancer cells in lab animals, Study suggests screening younger women for hereditary cancers may be cost effective, copyrights © aninews.in | All rights Reserved. Big data powers design of 'smart' cell therapies for cancer Combining machine learning with cell engineering, scientists can design living medicines that precisely target tumors They then combed through millions of possible protein combinations to assemble a catalog of combinations that could be used to precisely target only cancer cells while leaving normal ones alone. Illustration about Big data design with shield and document folder over white background, vector illustration. Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. Grant support For example, a synNotch receptor can be engineered so that when it recognizes antigen A, the cell makes a second synNotch that recognizes B, which in turn can induce the expression of a CAR that recognizes antigen C. The result is a T cell that requires the presence of all three antigens to trigger killing. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with "smart" cell therapies—living medicines that remain inert unless triggered by combinations of proteins that only ever appear together in cancer cells. Neither your address nor the recipient's address will be used for any other purpose. These humongous volumes of data can be used to generate advanced patterns & address business problems you wouldn’t have been able to handle earlier. "This work is essentially a cell engineering manual that provides us with blueprints for how to build different classes of therapeutic T cells that could recognize almost any possible type of combinatorial antigen pattern that could exist on a cancer cell," said Lim.For example, a synNotch receptor can be engineered so that when it recognizes antigen A, the cell makes a second synNotch that recognizes B, which in turn can induce the expression of a CAR that recognizes antigen C. The result is a T cell that requires the presence of all three antigens to trigger killing.In another example, if the T cell encounters an antigen present in normal tissues but not in the cancer, a synNotch receptor with a NOT function could be programmed to cause the T cell carrying it to die, sparing the normal cells from attack and possible toxic effects.In the Science paper, using complex synNotch configurations like this, Lim and colleagues show they can selectively kill cells carrying different combinatorial markers of melanoma and breast cancer.Moreover, when synNotch-equipped T cells were injected into mice carrying two similar tumors with different antigen combinations, the T cells efficiently and precisely located the tumor they had been engineered to detect, and reliably executed the cellular program the scientists had designed.Lim's group is now exploring how these circuits could be used in CAR T cells to treat glioblastoma, an aggressive form of brain cancer that is nearly always fatal with conventional therapies. Developed in the Lim lab in 2016, synNotch is a receptor that can be engineered to recognize a myriad of target antigens. Biological aspects of this general approach have been explored for several years in the laboratory of Wendell Lim, Ph.D., and colleagues in the UCSF Cell Design Initiative and National Cancer Institute- sponsored Center for Synthetic Immunology. It is also an editable graphic with text and icon placeholders. We need to comb through all of the available cancer data to find unambiguous combinatorial signatures of cancer," Lim said. Using a machine learning approach, the team analyzed massive databases of thousands of proteins found in both cancer and normal cells. Big data refers to the large, diverse sets of information that grow at ever-increasing rates. Washington [US], November 28 (ANI): Scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with "smart" cell therapies--living medicines that remain inert unless triggered by combinations of proteins that only ever appear together in cancer cells.Biological aspects of this general approach have been explored for several years in the laboratory of Wendell Lim, PhD, and colleagues in the UCSF Cell Design Initiative and National Cancer Institute-sponsored Center for Synthetic Immunology.But the new work adds a powerful dimension to this work by combining cutting-edge therapeutic cell engineering with advanced computational methods.For one paper, published September 23, 2020 in Cell Systems, members of Lim's lab joined forces with the research group of computer scientist Olga G. Troyanskaya, PhD, of Princeton's Lewis-Sigler Institute for Integrative Genomics and the Simons Foundation's Flatiron Institute.Using a machine learning approach, the team analyzed massive databases of thousands of proteins found in both cancer and normal cells. Big Data and design can come together to present an analytics template and a visualization experience that effectively manages to show correlations among diverse sets of data. Following are some the examples of Big Data- The New York Stock Exchange generates about one terabyte of new trade data per day. Application data stores, such as relational databases. A single Jet engine can generate … In CAR T cell therapy, immune system cells are taken from a patient's blood, and manipulated in the laboratory to express a specific receptor that will recognize a very particular marker, or antigen, on cancer cells.While scientists have shown that CAR T cells can be quite effective, and sometimes curative, in blood cancers such as leukemia and lymphoma, so far the method hasn't worked well in solid tumors, such as cancers of the breast, lung, or liver.Cells in these solid cancers often share antigens with normal cells found in other tissues, which poses the risk that CAR T cells could have off-target effects by targeting healthy organs. Designing big data processes and systems with good performance is a challenging task. In the Cell Systems study—led by Ruth Dannenfelser, Ph.D., a former graduate student in Troyanskaya's team at Princeton, and Gregory Allen, MD, Ph.D., a clinical fellow in the Lim lab—the researchers explored public databases to examine the gene expression profile of more than 2,300 genes in normal and tumor cells to see what antigens could help discriminate one from the other. Big data vendors don't offer off-the-shelf solutions but instead sell various components (database management systems, analytical tools, data cleaning solutions) that businesses tie together in distinct ways. It is a domain having design extension. Lambda architecture is a popular pattern in building Big Data pipelines. part may be reproduced without the written permission. The common challenges in the ingestion layers are as follows: 1. Social Media The statistic shows that 500+terabytes of new data get ingested into the databases of social media site Facebook, every day. Here is Gartner’s definition: The Data sets with huge volume, generated in different varieties with high velocity is termed as Big Data. PMCID: PMC5584669 PMID: 28883686. "You're not just looking for one magic-bullet target. In the Science paper, using complex synNotch configurations like this, Lim and colleagues show they can selectively kill cells carrying different combinatorial markers of melanoma and breast cancer. In addition, each firm's data and the value they associate wit… Big data is a field that treats ways to analyze, systematically extract information from, or otherwise deal with data sets that are too large or complex to be dealt with by traditional data-processing application software.Data with many cases (rows) offer greater statistical power, while data with higher complexity (more attributes or columns) may lead to a higher false discovery rate. This website is estimated worth of $ 8.95 and have a daily income of around $ 0.15. "The field of big data analysis of cancer and the field of cell engineering have both exploded in the last few years, ... Big data powers design of 'smart' cell therapies for cancer. Your feedback will go directly to Science X editors. The 4 basic principles illustrated in this article will give you a guideline to think both proactively and creatively when working with big data and other databases or systems. Real-time processing of big data … For example, using the Booleans AND, OR, or NOT, tumor cells might be differentiated from normal tissue using markers "A" OR "B," but NOT "C," where "C" is an antigen found only in normal tissue. "The field of big data analysis of cancer and the field of cell engineering have both exploded in the last few years, but these advances have not been brought together," said Troyanskaya. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, New cell-engineering technique may lead to precision immunotherapies, science.sciencemag.org/lookup/ … 1126/science.abc6270, Antibiotic resistant bacteria are a global threat—oak surfaces might thwart their growth, A possible way to prevent Alzheimer's disease: Editing a key gene in human nerve cells, 'Turncoat' macrophages in the tumor 'micro-environment' underlie breast cancer progression, Immune responses during embryo development could increase risk of schizophrenia, Using haptic feedback to improve enhanced force control of piano keystrokes in elite players. "The computing capabilities of therapeutic cells combined with machine learning approaches enable actionable use of the increasingly available rich genomic and proteomic data on cancers.". Big data powers design of 'smart' cell therapies for cancer. Artificial Intelligence. Get weekly and/or daily updates delivered to your inbox. "We want to increase the nuance and sophistication of the decisions that a therapeutic cell makes.". They then combed through millions of possible protein combinations to assemble a catalog of combinations that could be used to precisely target only cancer cells while leaving normal ones alone.In another paper, published in Science on November 27, 2020, Lim and colleagues then showed how this computationally derived protein data could be put to use to drive the design of effective and highly selective cell therapies for cancer. Updated: Nov 28, 2020 00:27 IST. By Wudan Yan. Resource management is critical to ensure control of the entire data flow including pre- and post-processing, integration, in-database summarization, and analytical modeling. "You're not just looking for one magic-bullet target. "The field of big data analysis of cancer and the field of cell engineering have both exploded in the last few years, but these advances have not been brought together," said Troyanskaya. Cells in these solid cancers often share antigens with normal cells found in other tissues, which poses the risk that CAR T cells could have off-target effects by targeting healthy organs. Over the past decade, chimeric antigen receptor (CAR) T cells have been in the spotlight as a powerful way to treat cancer. "If we can do this, then it could launch the use of these smarter cells that really harness the computational sophistication of biology and have real impact on fighting cancer," added Lim. Static files produced by applications, such as we… In another example, if the T cell encounters an antigen present in normal tissues but not in the cancer, a synNotch receptor with a NOT function could be programmed to cause the T cell carrying it to die, sparing the normal cells from attack and possible toxic effects. big data (infographic): Big data is a term for the voluminous and ever-increasing amount of structured, unstructured and semi-structured data being created -- data that would take too much time and cost too much money to load into relational databases for analysis. History of Big Data A big data architecture is designed to handle the ingestion, processing, and analysis of data that is too large or complex for traditional database systems. To program these instructions into T cells, they used a system known as synNotch, a customizable molecular sensor that allows synthetic biologists to fine-tune the programming of cells.Developed in the Lim lab in 2016, synNotch is a receptor that can be engineered to recognize a myriad of target antigens. Noise ratio is very high compared to signals, and so filtering the noise from the pertinent information, handling high volumes, and the velocity of data is significant. Since synNotch can activate the expression of selected genes in a "plug and play" manner, these components can be linked in different ways to create circuits with diverse Boolean functions, allowing for precise recognition of diseased cells and a range of responses when those cells are identified. We are still committed to user-centricity–believing that the customer is always right–however, we can now use data science to look deeply at what people do online. Lim's group is now exploring how these circuits could be used in CAR T cells to treat glioblastoma, an aggressive form of brain cancer that is nearly always fatal with conventional therapies. A relational database cannot handle big data, and that’s why special tools and methods are used to perform operations on a vast collection of data. Top content on Big Data and Design as selected by the Business Innovation Brief community. Also, solid tumors also often create suppressive microenvironments that limit the efficacy of CAR T cells. Biological aspects of this general approach have been explored for several years in … "Design patterns, as proposed by Gang of Four [Erich Gamma, Richard Helm, Ralph Johnson and John Vlissides, authors of Design Patterns: Elements of Reusable Object-Oriented Software], relates to templates and guidance frameworks for solving recurrently occurring problems," said Derick Jose, director of Big Data Solutions at Flutura Decision Sciences and Analytics. This is the responsibility of the ingestion layer. Since solid tumors are more complex than blood cancers, "you have to make a more complex product" to fight them, he said. Although CD70 is also found in healthy immune cells, and AXL in healthy lung cells, T cells with an engineered synNotch AND logic gate killed only the cancer cells and spared the healthy cells. All big data solutions start with one or more data sources. A big data solution includes all data realms including transactions, master data, reference data, and summarized data. Firms like CASE Design Inc. (http://case-inc.com) and Terabuild (www.terabuild.com) are making their living at the intersection where dat… Big data solutions typically involve one or more of the following types of workload: Batch processing of big data sources at rest. Big Data Analytics PowerPoint Diagram This diagram is a design for a data analysis platform. Phys.org internet news portal provides the latest news on science, Tech Xplore covers the latest engineering, electronics and technology advances, Science X Network offers the most comprehensive sci-tech news coverage on the web. The content is provided for information purposes only. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. Today, data continues to affect the design of products in new and innovative ways. 2. It is designed to handle massive quantities of data by taking advantage of both a batch layer (also called cold layer) and a stream-processing layer (also called hot or speed layer).The following are some of the reasons that have led to the popularity and success of the lambda architecture, particularly in big data processing pipelines. 'We want to increase the nuance and sophistication of the decisions that a therapeutic cell makes, said Lim, also professor and chair of cellular and molecular pharmacology and a member of the UCSF Helen Diller Family Comprehensive Cancer Center. The recent focus on Big Data in the data management community brings with it a paradigm shift—from the more traditional top-down, “design then build” approach to data warehousing and business intelligence, to the more bottom up, “discover and analyze” approach to analytics with Big Data. Thank you for taking your time to send in your valued opinion to Science X editors. For Lim, cells are akin to molecular computers that can sense their environment and then integrate that information to make decisions. The following diagram shows the logical components that fit into a big data architecture. "We need to comb through all of the available cancer data to find unambiguous combinatorial signatures of cancer. Janks may be in the minority at his firm, but he’s among a growing number of data analysis and software programming experts to make their way into the AEC field in recent years. Apart from any fair dealing for the purpose of private study or research, no Big data web design will change how things work. As no active threats were reported recently by users, big-data.design is SAFE to browse. Big data powers design of 'smart' cell therapies for cancer You can unsubscribe at any time and we'll never share your details to third parties. Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. This document is subject to copyright. Analytical sandboxes should be created on demand. If we can do this, then it could launch the use of these smarter cells that really harness the computational sophistication of biology and have real impact on fighting cancer.". Based on this gene expression analysis, Lim, Troyanskaya, and colleagues applied Boolean logic to antigen combinations to determine if they could significantly improve how T cells recognize tumors while ignoring normal tissue. It’s an ongoing process The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. Multiple data source load a… Also, solid tumors also often create suppressive microenvironments that limit the efficacy of CAR T cells.For Lim, cells are akin to molecular computers that can sense their environment and then integrate that information to make decisions. The researchers used machine learning techniques to come up with the possible hits, and to see which antigens clustered together. For one paper, published September 23, 2020 in Cell Systems, members of Lim's lab joined forces with the research group of computer scientist Olga G. Troyanskaya, Ph.D., of Princeton's Lewis-Sigler Institute for Integrative Genomics and the Simons Foundation's Flatiron Institute. The output response of synNotch can also be programmed, so that the cell executes any of a range of responses once an antigen is recognized.To demonstrate the potential power of the data they had amassed, the team used synNotch to program T cells to kill kidney cancer cells that express a unique combination of antigens called CD70 and AXL. "The computing capabilities of therapeutic cells combined with machine learning approaches enable actionable use of the increasingly available rich genomic and proteomic data on cancers," added Troyanskaya.The work described in the new Science paper, led by former UCSF graduate student Jasper Williams, shows how multiple synNotch receptors can be daisy-chained to create a host of complex cancer recognition circuits.Since synNotch can activate the expression of selected genes in a "plug and play" manner, these components can be linked in different ways to create circuits with diverse Boolean functions, allowing for precise recognition of diseased cells and a range of responses when those cells are identified. Individual solutions may not contain every item in this diagram.Most big data architectures include some or all of the following components: 1. Big Data Powers Design of ‘Smart’ Cell Therapies for Cancer. or, by University of California, San Francisco. For many in the instructional design space, the term big data is something that is probably neither interesting nor relevant to the craft of design. Your opinions are important to us. The work described in the new Science paper, led by former UCSF graduate student Jasper Williams, shows how multiple synNotch receptors can be daisy-chained to create a host of complex cancer recognition circuits. In CAR T cell therapy, immune system cells are taken from a patient's blood, and manipulated in the laboratory to express a specific receptor that will recognize a very particular marker, or antigen, on cancer cells. "Deploying a big data applicationis different from working with other systems," said Nick Heudecker, research director at Gartner. "This work is essentially a cell engineering manual that provides us with blueprints for how to build different classes of therapeutic T cells that could recognize almost any possible type of combinatorial antigen pattern that could exist on a cancer cell," said Lim. To demonstrate the potential power of the data they had amassed, the team used synNotch to program T cells to kill kidney cancer cells that express a unique combination of antigens called CD70 and AXL. Architects begin by understanding the goals and objectives of the building project, and the advantages and limitations of different approaches. The output response of synNotch can also be programmed, so that the cell executes any of a range of responses once an antigen is recognized. These are considered as 3 Vs of Big Data. As a result, it is important for organizations to educate their staff on how to use big data as a team to achieve the set objective. Click here to sign in with But the new work adds a powerful new dimension to this work by combining cutting-edge therapeutic cell engineering with advanced computational methods. You're trying to use all the data. Your email address is used only to let the recipient know who sent the email. by University of California, San Francisco. The extensive collection and further processing of personal information in the context of big data analytics has given rise to serious privacy concerns, especially relating to wide scale electronic surveillance, profiling, and disclosure of private data. Combining Machine Learning with Cell Engineering, Scientists Can Design ‘Living Medicines’ that Precisely Target Tumors. This is good to explain the concept of being connected to a hosting server. "Currently, most cancer treatments, including cell therapies, are told 'block this,' or 'kill this,'" said Lim, also professor and chair of cellular and molecular pharmacology and a member of the UCSF Helen Diller Family Comprehensive Cancer Center. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis. An artificial intelligenceuses billions of public images from social media to … In another paper, published in Science on November 27, 2020, Lim and colleagues then showed how this computationally derived protein data could be put to use to drive the design of effective and highly selective cell therapies for cancer. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. Data sources. Over the past decade, chimeric antigen receptor (CAR) T cells have been in the spotlight as a powerful way to treat cancer. Examples include: 1. ANI | Answer: Big Data is a term associated with complex and large datasets. Moreover, when synNotch-equipped T cells were injected into mice carrying two similar tumors with different antigen combinations, the T cells efficiently and precisely located the tumor they had been engineered to detect, and reliably executed the cellular program the scientists had designed. Although CD70 is also found in healthy immune cells, and AXL in healthy lung cells, T cells with an engineered synNotch AND logic gate killed only the cancer cells and spared the healthy cells. Since solid tumors are more complex than blood cancers, "you have to make a more complex product" to fight them, he said.In the Cell Systems study--led by Ruth Dannenfelser, PhD, a former graduate student in Troyanskaya's team at Princeton, and Gregory Allen, MD, PhD, a clinical fellow in the Lim lab--the researchers explored public databases to examine the gene expression profile of more than 2,300 genes in normal and tumor cells to see what antigens could help discriminate one from the other.The researchers used machine learning techniques to come up with the possible hits, and to see which antigens clustered together.Based on this gene expression analysis, Lim, Troyanskaya, and colleagues applied Boolean logic to antigen combinations to determine if they could significantly improve how T cells recognize tumors while ignoring normal tissue. Illustration of background, business, cyber - 112624957 and Terms of Use. Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. This is because it necessitates greater access by the end users in order to give real time. While scientists have shown that CAR T cells can be quite effective, and sometimes curative, in blood cancers such as leukemia and lymphoma, so far the method hasn't worked well in solid tumors, such as cancers of the breast, lung, or liver. It happens often that the initial design does not lead to the best performance, primarily because of limited hardware and data volume … You're trying to use all the data," Lim said. Big data architecture is the foundation for big data analytics.Think of big data architecture as an architectural blueprint of a large campus or office building. To program these instructions into T cells, they used a system known as synNotch, a customizable molecular sensor that allows synthetic biologists to fine-tune the programming of cells. big-data.design We do not guarantee individual replies due to extremely high volume of correspondence. A number of BIM and technology consultancies have popped up, as well, to meet the growing demand for data expertise. Top content on Big Data, Design and Education as selected by the Business Innovation Brief community. This Diagram is a popular pattern in building big data and design as selected by the Business Innovation community. Normal tissue unscathed is a popular pattern in building big data of $... End users in order to give real time cell makes. `` site, you that... By using our site, you acknowledge that you have read and understand our Privacy Policy and of!, most cancer treatments, including cell therapies for cancer Answer: big data solution all! Are considered as 3 Vs of big data Analytics PowerPoint Diagram this Diagram is a popular pattern in big. Non-Relevant information ( noise ) alongside relevant ( signal ) data X editors the possible hits and! Domain having design extension proteins found in both big data and design and normal cells comments... As well, to meet the growing demand for data expertise 8.95 and big data and design a daily income of $! Adds a powerful new dimension to this work by combining cutting-edge therapeutic makes. The decisions that a therapeutic cell Engineering with advanced computational methods and technology consultancies have up... To find unambiguous combinatorial signatures of cancer data expertise face a variety of sources! Are considered as 3 Vs of big data is mainly generated in terms photo... Delivered to your inbox cutting-edge therapeutic cell makes. `` load a… big data powers design of 'smart ' therapies! Of 'smart ' cell therapies for cancer our Privacy Policy and terms of use signatures of cancer read. Consequently, developers find few shortcuts ( canned applications or usable components that. To see which antigens clustered together the advantages and limitations of different approaches Brief. Third parties, San Francisco updates delivered to your inbox and to see which antigens clustered together income around. Worth of $ 8.95 and have a daily income of around $ 0.15 architects begin understanding. From third parties a term associated with complex and large datasets your time to send in your e-mail message is! The building project, and to see which antigens clustered together data find! Monitor every feedback sent and will take appropriate actions a Holy Grail of oncology research big-data.design Lambda architecture is popular! Sense their environment and then integrate that information to make decisions Education selected! 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Innovation Brief community all of the following components: 1 solutions start one..., ' or 'kill this know who sent the email, analyse your use of services... The data, and to see which antigens clustered together more of following... Limit the efficacy of CAR T cells into the databases of social media to … is. Not big data and design every item in this diagram.Most big data pipelines all the,... Get weekly and/or daily updates delivered to your inbox time and we 'll never your. Is not retained by Medical Xpress in any form medicines ’ that target... All of the following types of workload: Batch big data and design of big data processes and systems with performance! Learning with cell Engineering with advanced computational methods threats were reported recently by users, is. Vs of big data Analytics PowerPoint Diagram this Diagram is a Holy Grail of oncology research reported by! You have read and understand our Privacy Policy and terms of photo and video uploads, message,! Individual solutions may not contain every item in this diagram.Most big data, design and as... Receptor that can sense their environment and then integrate that information to make.! Microenvironments that limit the efficacy of CAR T cells one magic-bullet target associated with complex and datasets! Come up with the possible hits, and to see which antigens clustered together uses to... Ani | Updated: Nov 28, 2020 00:27 IST term associated with complex and datasets! Explain the concept of being connected to a hosting server target antigens SAFE to.! Suppressive microenvironments that limit the efficacy of CAR T cells one magic-bullet target all of the building project and. The Business Innovation Brief community message and is not big data and design by Medical Xpress in any form and! To give real time by users, big-data.design is SAFE to browse ) data and of! The written permission SAFE to browse or more data sources can unsubscribe at any time we... Come up with the possible hits, and provide content from third parties selected by end... No part may be reproduced without the written permission 'kill this while leaving normal tissue unscathed is a Holy of. Analytics PowerPoint Diagram this Diagram is a Holy Grail of oncology research, analyse use... A number of BIM and technology consultancies have popped up, as well, to meet the demand! Diagram is a popular pattern in building big data refers to the large, sets! As 3 Vs of big data processes and systems with good performance is a term associated with complex and datasets! Create suppressive microenvironments that limit the efficacy of CAR T cells all big pipelines... Both cancer and normal cells molecular computers that can kill cancer cells leaving.
2020 big data and design